CORDIS Project
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This project aims to explore the mechanisms of cell lineage segregation in early mouse embryos using advanced imaging techniques. By understanding how cells divide and sort themselves, the research seeks to elucidate the physical dynamics that govern embryonic development.
In mammalian development, the first cell lineages are established in the blastocyst, in which the inner cell mass (ICM) and the trophectoderm (TE) occupy distinct compartment along the embryonic inner-outer axis.
The inner and outer cell layers in the embryo are generated during the transition from the 8-cell to 32-cell stage in principle by two dynamic processes, cell division and cell sorting.
However, the mechanism by which the spindle orientation and cellular movement are regulated in the ea…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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