CORDIS Project
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This project investigates the dynamics and regulation of the actin cytoskeleton in embryonic cells, using the early C. elegans embryo as a model. It focuses on understanding how actin structures are formed and maintained, which is crucial for processes like cell division and morphogenesis.
In embryonic cells, actomyosin forms a cortical reticulated gel that turns over rapidly, is weakly organized, and is composed of a variety of structures, with distinct architectures and dynamics, which are nucleated and elongated by different factors, and bind to specific sets of actin-binding proteins that modulate their dynamics.
Understanding how actin is distributed between these structures is critical to understand the biology and mechanics of the actin cytoskeleton and therefore its role i…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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