CORDIS Project
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This project focuses on understanding the autophagy process by creating modified LC3 proteins that can help study the formation and function of autophagosomes. These proteins will serve as valuable tools for investigating the molecular mechanisms involved in cellular degradation and recycling.
Autophagy is a cellular pathway that regulates the degradation and recycling of proteins and organelles.
This mechanism is initiated with the formation of a phagophore, a cup-shaped double membrane that engulfs the cytoplasmic material to be degraded.
The phagophore is then elongated and sealed to generate an autophagosome that will be fused with a lysosome, thereby delivering the cargo for degradation.
Several ubiquitin-like proteins have been shown to have a crucial role in regulating autophag…
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