CORDIS Project
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This project investigates the process of autophagy, which is crucial for cellular health and linked to diseases like cancer. By developing novel chemical probes, it aims to better understand the formation of autophagosomes and the role of specific proteins in this process.
The interest on autophagy, an evolutionarily conserved process in eukaryotes, has enormously increased in the last years, since autophagy is involved in many diseases such as cancer and neurodegenerative disorders.
Autophagosome formation is the key process in autophagy.
Despite extensive work, the model of autophagosome formation is not yet well established.
Some important questions on autophagosome biogenesis remain to be elusive, such as where the bona fide marker protein of autophagosome, LC…
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