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ChemBioChol focuses on understanding cholesterol transport proteins by developing selective small molecule modulators. The project aims to create tools for determining lipid selectivity and to explore the roles of these proteins in lipid metabolism, with potential applications in neurodegenerative disorders and cancer.
Cholesterol transport proteins (CTPs) regulate cellular metabolism, hormone biosynthesis, and organelle contacts, with profound consequences for human health and disease.
Despite this, almost no small molecule CTP modulators have been reported, and no methods for determining selectivity across the broader protein class exist.
Selective CTP inhibition is conceptually challenging as all CTPs are structurally similar and bind cholesterol.
Furthermore, due to redundancy among several CTPs, decipheri…
TECHNICAL UNIVERSITY OF DENMARK DTU
DANMARKS TEKNISKE UNIVERSITET
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