CORDIS Project
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This project investigates novel post-translational modifications of histones, specifically lysine malonylation and succinylation, and their roles in gene regulation and disease. It aims to develop tools for analyzing these modifications and their biological significance.
A large body of evidence suggest that reversible post-translational modifications (PTMs) of histones play a crucial role in gene expression and to the field of epigenetics, and that aberrant histone modification contributes to different diseases such as cancer.
Recently, two novel types of histone PTMs called lysine malonylation (Kmal) and succinylation (Ksucc) have been identified. KMal and Ksucc induce more substantial chemical changes to the chemical properties of the modified protein than ly…
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