CORDIS Project
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This project focuses on improving the synthesis of chiral compounds for pharmaceuticals by developing new catalytic processes. It aims to create efficient methods for forming complex three-dimensional structures directly from simpler precursors, enhancing sustainability and reducing waste in drug production.
Over 60% of the world’s top selling small molecule drug compounds are chiral and, of these, approximately 80% are marketed as single enantiomers.
Surprisingly, and despite the tremendous advances made in catalysis over the past several decades, the average “chiral complexity” of drug discovery libraries has actually decreased, while, at the same time the “chiral complexity” of marketed drugs has increased.
Consequently, there is now an urgent need to provide efficient processes that access direc…
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