CORDIS Project
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The CHIMERA project seeks to enhance the effectiveness of immunotherapy in colorectal cancer by converting immune-cold tumors into immune-hot tumors. It combines a new MMR inhibitor with cytotoxic agents to increase tumor mutational burden, aiming to broaden the applicability of immunotherapy.
In colorectal cancer (CRC), the efficacy of immunotherapy is currently limited to a small subgroup of tumors characterized by mismatch repair (MMR) deficiency.
Conversely, little or no clinical benefit has been shown in the large majority of CRCs with MMR proficiency, which are accordingly defined as immune-cold tumors.
Determining how to turn an immune-cold into a hot (immunotherapy responsive) tumor remains a major scientific challenge and an unmet clinical need.
Building on our recent demonst…
UNIVERSITA DEGLI STUDI DI TORINO
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