CORDIS Project
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The project aims to improve organ transplant outcomes by developing donor-specific regulatory T cells using chimeric antigen receptor technology. This approach seeks to promote tolerance and reduce the risk of rejection in kidney transplants.
Organ transplantation is the best life-supporting treatment for terminal organ failure.
Graft survival is however limited by rejection, a destructive process resulting from the response of recipient’s immune system against donor specific alloantigens.
Prevention of rejection currently relies on immunosuppressive drugs that lack antigen specificity and therefore increase the risk for infections and cancers.
Induction of donor-specific tolerance would provide indefinite graft survival without morb…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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Canada, Vancouver
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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