CORDIS Project

The role of the non-canonical death receptor signalling in cancer and immune cells

CHIRON·101130240·HORIZON

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View on CORDIS DOI grant

Funding data

Programme: Horizon Europe
Participants: 4
Start - End: 01/10/2023 — 30/09/2027
Status: SIGNED

Summary

The CHIRON project investigates immune surveillance mechanisms in cancer, specifically focusing on the TRAIL signaling pathway. It aims to develop small molecule inhibitors to enhance the effectiveness of immune responses against tumor cells and improve diagnostic and therapeutic strategies.

Objective

Immune surveillance refers to the ability of the immune system to efficiently induce cell death (apoptosis) in aberrant cells during the early stages of tumour development.

This induction of cell death involves the binding of the death ligand TRAIL (TNF-related apoptosis-inducing ligand) to its death receptors (DRs) DR4 and DR5 on the target cell.

However, tumour cells can escape this immune surveillance by switching the signalling downstream of DRs from the canonical pro-apoptotic signal toward…

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Coordinator

IZMIR BIOMEDICINE AND GENOME CENTER

IZMIR BIYOTIP VE GENOM MERKEZI

Country: Türkiye, İzmir
Organization type: Research institute
Activity type: Research Organisations
SME: Yes

Network and participants(4 participants)

Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.

CHALMERS VENTURES AB
Sweden, Gothenburg
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
participant
BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS
Hungary, Budapest
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant
COVALAB
France, Bron
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
participant
DOKUZ EYLUL UNIVERSITY
Türkiye, Alsancak Izmir
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant

4 participants shown of 10

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CORDIS call / funding scheme

Programme: HORIZON
Call: HORIZON-MSCA-2022-SE-01
Sub call: HORIZON-MSCA-2022-SE-01
Funding scheme: HORIZON-TMA-MSCA-SE
Domain note: This block describes the CORDIS project call context. Live open opportunities are managed in the Funding & Tenders domain.

Fields of Science (EuroSciVoc)

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Medical and health sciencesClinical medicineOncology

Topic

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HORIZON-MSCA-2022-SE-01-01

Keywords

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TRAIL death receptors DR4 DR5