CORDIS Project
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This project aims to identify and characterize enzymes responsible for chlorination in plants, specifically focusing on iridoid glycosides in the Phlomis genus. By sequencing plant transcriptomes and conducting biochemical assays, the research seeks to uncover the mechanisms behind chlorinated natural product synthesis…
A plethora of halogenated natural products documents the existence of halogenases in plants but the responsible enzymes remain elusive.
Chlorinated iridoid glycosides, for instance, occur in Phlomis, a genus in the mint family.
Based on knowledge of iridoid biosynthesis and a mechanistic hypothesis for the chlorination reaction, we aim to discover the underlying enzymes.
We will sequence transcriptomes of Phlomis tissues in different metabolic states, identify homologs of enzymes involved in iri…
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