CORDIS Project
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This project investigates the molecular interactions between the endocytic adaptor protein ARH and the LDL receptor to understand how cholesterol is cleared from the bloodstream. By studying the structural and biochemical properties of these interactions, the research aims to enhance knowledge of cholesterol homeostasi…
Hypercholesterolemia, high levels of plasma LDL-cholesterol, is a major risk factor for atherosclerosis and premature coronary heart disease (CHD), a leading cause of death in worldwide.
The clearance of LDL from the circulation occurs via endocytosis with the LDL-receptor (LDLR) mainly by liver cells.
This hepatic recruitment of the LDL-LDLR complex to the clathrin-coated pits is dependent on the endocytic adaptor protein, autosomal recessive hypercholesterolemia (ARH), which recognizes the NPx…
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