CORDIS Project
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This project aims to investigate the role of the WWP2 ubiquitin ligase in osteoarthritis, focusing on its substrates and their impact on cartilage biology. The goal is to identify molecular targets for potential treatments of osteoarthritis and related conditions.
Osteoarthritis (OA), characterised by cartilage degradation, is the most common form of arthritis affecting >10% of the EU population over 60 years of age.
The pathogenesis is only poorly understood.
There is no cure available and current treatment involves pain relief and joint replacement surgery. WWP2 is an ubiquitin ligase involved in stem cell differentiation, cancer development and immune responses, and importantly plays crucial roles in chondrogenesis and craniofacial development.
However…
UNIVERSITY OF NEWCASTLE UPON TYNE
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United States, Washington D.C.
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SME: No
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