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CHOTENICS investigates the mechanisms of cholesterol transport within cells using a novel chemical genetics approach. By developing a high-content screening assay, the project aims to identify small molecules that can modulate cholesterol distribution, ultimately revealing transport pathways and potential therapeutic t…
Cholesterol is a unique lipid, essential for membrane integrity, cell signalling and cell proliferation.
Accordingly, mammalian organisms have evolved an elaborate myriad of mechanisms to control cholesterol transport and distribution within cells.
However, our understanding of these mechanisms remains incomplete due to (i) the functional redundancy inherent among cholesterol transporters, which limits their study through conventional genetic approaches, and (ii) the general lack of suitable pro…
TECHNICAL UNIVERSITY OF DENMARK DTU
DANMARKS TEKNISKE UNIVERSITET
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