CORDIS Project
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This project investigates the roles of long non-coding RNAs (lncRNAs) in breast cancer by identifying their complexes with chromatin binding proteins and their effects on histone modifications. Using advanced techniques, it aims to uncover how these interactions contribute to cancer development and progression.
It is now know that the mammalian genome encodes many thousands of long non-coding RNAs (lncRNAs, >200nt long), some of which are implicated in human pathogenesis including cancers. A subset of lncRNAs such as HOTAIR and ANRIL are overexpressed in several cancers and play roles in epigenetic gene regulation during carcinogenesis, mainly by recruiting chromatin modifier complexes to their target loci.
Interestingly, recent studies indicate that some lncRNAs including ANRIL bind to and act togethe…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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