CORDIS Project
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This project aims to understand how the spatial organization of topologically associating domains (TADs) in human cells affects genome function. Using advanced imaging techniques, it will visualize the DNA structure and the proteins that organize TADs, providing insights into chromatin architecture.
How can phenotypic variations emerge from cells that carry the same genetic information?
It is one of today’s great challenges to understand how genetic information is modulated inside the cell.
Over the last decade, insight from genome-wide proximity-based ligation approaches revealed that the genome is organised in a hierarchical manner with the help of structuring proteins, and that this spatial organisation regulates the core functions of the genome, such as transcription, replication and re…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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