CORDIS Project
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This project investigates how the organization of DNA into chromatin affects the detection and repair of DNA damage in human cells. By using advanced microscopy techniques, it aims to visualize chromatin dynamics during cellular responses to genotoxic stress and identify key regulatory factors involved in these process…
Protection of genome integrity is crucial for maintaining cell viability and preventing cancer.
However, how the dynamic organisation of DNA into chromatin in the cell nucleus is orchestrated in order to allow and promote detection and repair of DNA lesions remains poorly understood. A controlled accessibility of damaged chromatin is likely critical for an efficient cellular response to DNA damage, but underlying molecular mechanisms enabling this regulation have to be deciphered.
In this propos…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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France, Paris
Type: Research institute
Activity type: Research Organisations
SME: No
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