CORDIS Project
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This project investigates how cells repair DNA damage, which is crucial for preventing diseases like cancer. By identifying and characterizing chromatin-modifying enzymes involved in DNA repair, the research aims to enhance our understanding of genome stability.
Our cells receive tens of thousands of different DNA lesions per day.
Failure to repair these lesions will lead to cell death, mutations and genome instability, which contribute to human diseases such as neurodegenerative disorders and cancer.
Efficient recognition and repair of DNA damage, however, is complicated by the fact that genomic DNA is packaged, through histone and non-histone proteins, into a condensed structure called chromatin.
The DNA repair machinery has to circumvent this barrier…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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