CORDIS Project
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This project aims to investigate how RNA polymerase II transcribes genes within chromatin, the natural DNA structure in cells. By using integrated structural biology, it will reveal the mechanisms of transcription regulation on nucleosomal DNA, focusing on how chromatin influences transcription initiation and elongatio…
Transcription of protein-coding genes by RNA polymerase II (Pol II) governs cell identity and fate.
We previously provided the structural basis of Pol II transcription initiation (ERC Advanced Grant
TRANSIT:
Sainsbury, Nature 2012;
Lariviere, Nature 2012, Plaschka, Nature 2015) and of Pol II elongation regulation (ERC Advanced Grant
TRANSREGULON:
Vos, Nature 2018;
Vos & Farnung, Nature 2018).
These studies elucidated the mechanisms of transcription regulation.
However, they were conducted on nak…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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