CORDIS Project
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This project aims to develop a new workflow for identifying variable chromatin modules using single-cell ATAC-seq technology. By studying these modules, the project seeks to understand their role in gene regulation and their impact on metabolic diseases during human cell differentiation.
Most common disease-associated genetic variants are thought to fall into gene regulatory regions, where they affect the interaction between transcription factors (TFs) and DNA and induce transcriptional changes.
To understand the extent of, and the mechanisms underlying variation in binding of TFs to DNA, genome-wide TF and chromatin state profiling studies were performed which revealed that non-coding variants frequently mediate coordinated changes in TF binding and chromatin mark enrichment ov…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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