CORDIS Project
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This project investigates the structure of mitotic chromosomes in eukaryotic cells, focusing on the condensin complex's role in DNA compaction during cell division. Using yeast as a model, it aims to map condensin interactions and understand its regulation throughout the cell cycle.
Eukaryotic cells inherit much of their genomic information in the form of chromosomes during cell division.
Centimetre-long DNA molecules are packed into micrometer-sized chromosomes to enable this process.
How DNA is organised within mitotic chromosomes is still largely unknown. A key structural protein component of mitotic chromosomes, implicated in their compaction, is the condensin complex.
In this proposal, we aim to elucidate the molecular architecture of mitotic chromosomes, taking advant…
CANCER RESEARCH UK LBG
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