CORDIS Project
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This project investigates the mechanisms of chromosome folding, focusing on the roles of different activities of the SMC complex condensin. It aims to clarify how these activities contribute to chromosome stability and organization during cell division.
In human cells, the SMC complex condensin plays a significant and essential role in chromosome condensation, but there is conflicting data.
Studies from other groups have suggested that the loop extruding activity of condensin is important for chromosome folding, but a study from my host lab suggested that loop extrusion (LE) alone is not able to package chromosomes.
Using molecular biology experiments and polymer simulations they hypothesized that condensin has an additional bridging induced ph…
THE UNIVERSITY OF EDINBURGH
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