CORDIS Project
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This project investigates how variations in chromosome number affect organism health and development. By studying model organisms, it aims to uncover the mechanisms that maintain cellular stability and how these variations contribute to diseases like cancer.
How variations in whole chromosome number impact organism homeostasis remains an open question.
Variations to the normal euploid genome content are frequently found in healthy animals and are thought to contribute with phenotypic variability in adverse situations.
Yet they are also at the basis of several human diseases, including neuro-developmental disorders and cancer.
Our preliminary data shows that physiological aneuploidy can be identified in certain cells during development.
Moreover, we…
INSTITUT CURIE
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