CORDIS Project
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This project investigates the molecular mechanisms of epigenetic inheritance during chromosome replication. By reconstituting chromosome replication with purified proteins, it aims to understand how chromatin influences replication and gene expression patterns, enhancing our knowledge of epigenetics.
A PubMed search for ‘epigenetic’ identifies nearly 35,000 entries, yet the molecular mechanisms by which chromatin modification and gene expression patterns are actually inherited during chromosome replication — mechanisms which lie at the heart of epigenetic inheritance of gene expression — are still largely uncharacterised.
Understanding these mechanisms would be greatly aided if we could reconstitute the replication of chromosomes with purified proteins.
The past few years have seen great…
THE FRANCIS CRICK INSTITUTE LIMITED
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