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ChromoSilence investigates the role of Mitotic Transcriptional Inactivation (MTI) in cell division and genome stability. By using advanced techniques, the project aims to understand how MTI affects chromosome behavior and transcriptional control, ultimately revealing its importance in maintaining cell identity and supp…
Coordination between major cellular functions, such as transcription and proliferation, is critical to ensure cell survival.
It has long been recognised that while in mitosis, cells switch-off most of their transcriptional activity.
While Mitotic Transcriptional Inactivation (MTI) is entrenched as a dogma in cell biology, its functional consequences have been difficult to pin down, as manipulating MTI in the context of a developing organism has been difficult until now.
My lab has pioneered the…
UNIVERSIDADE CATOLICA PORTUGUESA
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