CORDIS Project
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This project investigates chromothripsis, a phenomenon where chromosomes undergo massive rearrangements, potentially impacting cancer development. It aims to understand the mechanisms behind chromothripsis using computational methods and cell line models to explore its role in tumorigenesis.
Recent cancer genome analyses have led to the discovery of a process involving massive genome structural rearrangement (SR) formation in a one-step, cataclysmic event, coined chromothripsis.
The term chromothripsis (chromo from chromosome; thripsis for shattering into pieces) stands for a hypothetical process in which individual chromosomes are pulverised, resulting in a multitude of fragments, some of which are lost to the cell whereas others are erroneously rejoined.
Compelling evidence was pr…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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