CORDIS Project
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This project investigates the mechanisms by which conventional dendritic cells engulf dead cells, focusing on their role in immune responses. It aims to identify the receptors involved in this process and their implications for anti-tumor immunity and tolerance.
The engulfment of dead cells by type 1 conventional dendritic cells (cDC1s) is essential to maintain tolerance to self-antigens and to induce immunity to infected or malignant cells. cDC1s have the unique ability to engulf dead cells, in contrast to the closely related cDC2s.
Moreover, uptake of apoptotic cells induces cDC1 maturation and serves as their key source of antigens.
However, we still do not understand which receptors on cDC1s are involved in the recognition and internalisation of dea…
THE FRANCIS CRICK INSTITUTE LIMITED
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