CORDIS Project
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This project explores the role of primary cilia in cell signaling, particularly focusing on the Hedgehog signaling pathway. By employing structural biology and live cell imaging, it aims to understand how proteins interact and regulate signaling within these cellular structures, with potential implications for cancer t…
The unexpected connection between the primary cilium and cell-to-cell signalling is one of the most exciting discoveries in cell and developmental biology in the last decade.
In particular, the Hedgehog (Hh) pathway relies on the primary cilium to fulfil its fundamental functions in orchestrating vertebrate development.
This microtubule-based antenna, up to 5 µm long, protrudes from the plasma membrane of almost every human cell and is the essential compartment for the entire Hh signalling casca…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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