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CiliaCircuits aims to explore the assembly and regulation of motile cilia, which are crucial for human health. The project will investigate the mechanisms behind dynein pre-assembly and ciliogenesis, with the goal of developing therapies for conditions like primary ciliary dyskinesia.
Motile cilia are tiny microtubule-based projections which create fluid flow and are essential to human health.
Cilia movement is powered by coordinated action of complex macromolecular motors, the axonemal dyneins.
During differentiation, as cells produce hundreds of motile cilia, millions of dynein subunits must be pre-assembled in the cytoplasm into very large complexes in the correct stoichiometry which are then trafficked into growing cilia.
This poses a sizeable challenge for the cell in te…
THE UNIVERSITY OF EDINBURGH
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