CORDIS Project
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This research explores the role of the CLOCK/CYCLE transcription factor in the circadian rhythms of fruit flies. It aims to understand how this factor influences adult neural clock circuits and behavior, with implications for human health.
Circadian clocks are internal daily time keeping mechanisms that are required for autonomous daily rhythms in physiology and behaviour of both fruit flies and humans.
Our previous work has identified a developmental role in fruit flies for the transcription factor CLOCK/CYCLE (CLK/CYC), which represents a phylogenetic and functional orthologue of the key human circadian regulator CLOCK/BMAL1.
By conditionally manipulating the developmental expression of the genes for CYC as well as the CLK/CYC i…
UNIVERSITY OF SOUTHAMPTON
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