CORDIS Project
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This project investigates how the mammalian circadian clock influences liver metabolism by regulating mRNA translation. It aims to identify genes translated rhythmically in the liver and the underlying mechanisms, focusing on the role of the Target Of Rapamycin Complex 1 in this process.
The mammalian circadian clock plays a fundamental role in the liver by regulating fatty acid, glucose and xenobiotic metabolism.
Impairment of this rhythm has been show to lead to diverse pathologies including metabolic syndrome.
At present, it is supposed that the circadian clock regulates metabolism mostly by regulating the expression of liver enzymes at the transcriptional level.
We have now collected evidence that post-transcriptional regulations play also an important role in this regulatio…
NESTEC SA
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Switzerland, LAUSANNE
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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