CORDIS Project
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This project investigates the role of stem cells in muscle regeneration, focusing on how aging affects their function. It explores the relationship between autophagy and circadian rhythms in these cells, aiming to enhance their regenerative capabilities through nutritional interventions and genetic modifications in mic…
Regeneration of skeletal muscle relies on its stem cells, also called satellite cells (SCs).
These cells remain quiescent throughout their life, and only activate in response to injury to form new muscle fibers.
The regenerative capacity of these cells declines with aging.
In the past years, Pura Muñoz Cánoves’ lab showed that, with aging, quiescent SCs 1) lose basal autophagy and 2) reprogram their circadian transcriptome (including the autophagic transcriptome).
The molecular bases of these pr…
UNIVERSIDAD POMPEU FABRA
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