CORDIS Project
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This project develops a personalized model for studying bone-related cancers using human ossicle technology, which creates miniaturized bone organs from patient-derived cells. It aims to improve the testing of immunotherapies by mimicking the patient's bone microenvironment, addressing limitations of current animal mod…
Bones represent a privileged site for cancer initiation and metastasis.
Yet, current in vitro and animal models fall short in accurately recapitulating bone-developing cancers.
To address this, we developed the human ossicle (hOss) technology: the in vivo formation of miniaturized bone organs composed of patient-derived bone and marrow cells.
By mimicking the patient’s bone microenvironment, hOss offer a personalized model for studying bone-related cancers.
To ensure reproducibility and standard…
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