CORDIS Project
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This project investigates how G protein-coupled receptors (GPCRs) create localized signaling units for cyclic adenosine monophosphate (cAMP) at nanometer scales, enabling precise cell functions. It employs advanced imaging and biosensing technologies to map these nanoswitches, focusing on their role in insulin secretio…
G protein-coupled receptors (GPCRs) relay extracellular information across the cell membrane to mediate most physiological cell functions.
Many cell-surface GPCRs stimulate the production of cyclic adenosine monophosphate (cAMP), a diffusible second messenger, to elicit receptor-specific, long-range cell functions.
However, given the mobility of second messengers, this canonical model fails to explain receptor-specific functions across multiple GPCRs that signal via cAMP.
This application propos…
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
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