CORDIS Project
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This project explores the role of the sympathetic nervous system in fat loss by activating nerve inputs to adipose tissues. It aims to understand the development of autonomic innervation and the cellular architecture of adipose tissue using advanced imaging techniques.
Obesity is a metabolic disorder with unmet medical intervention strategies, for which a therapy is urgently needed.
The Domingos Lab recently discovered that sympathetic (SNS) neuro-adipose junctions mediate lipolysis and fat mass reduction (Zeng et al., 2015).
Thus, direct and targeted activation of SNS inputs to adipose tissues (AT) could represent a new strategy for the induction of fat loss that would circumvent central leptin resistance as well as historical challenges associated with drug…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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