CORDIS Project
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This project aims to develop a novel gene therapy approach for treating severe myocardial ischemia by activating the body's own vascular growth factors. It focuses on a new technology that enhances natural angiogenesis through targeted gene regulation, with the potential for broader applications in medicine.
Background:
Therapeutic angiogenesis with vascular endothelial growth factors (VEGFs) has great potential to become a novel, minimally invasive new treatment for a large number of patients with severe myocardial ischemia.
However, this requires development of new technology.
Advancing state-of-the-art:
We propose a paradigm shift in gene therapy for chronic ischemia by activating endogenous VEGF-A,-B and -C genes and angiogenic transcription programs from the native promoters instead of gene tra…
UNIVERSITY OF EASTERN FINLAND (UEF)
ITA-SUOMEN YLIOPISTO
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