CORDIS Project
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This project investigates how neurons manage synaptic function through the regulation of RNA processes. By studying RNA-binding proteins and their interactions with RNA, the research aims to uncover mechanisms that influence neuronal activity and could lead to new treatments for neurodegenerative diseases.
An important question of modern neurobiology is how neurons regulate synaptic function in response to excitation.
In particular, the roles of alternative pre-mRNA splicing and mRNA translation regulation in this response are poorly understood.
We will study the RNA-binding proteins (RBPs) that control these post-transcriptional changes using a UV crosslinking-based purification method (CLIP) and ultra-high throughput sequencing.
Computational analysis of the resulting data will define the sequen…
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