CORDIS Project
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This project studies the clonal evolution of chronic lymphocytic leukemia (CLL) to understand how genetic changes influence disease progression. By analyzing patient samples over time, it aims to identify early genetic events that dictate tumor behavior.
Clonal evolution represents a central feature of tumor progression and relapse.
Chronic lymphocytic leukemia (CLL) is a valuable model to study this process due to a high prevalence, initially slow progression and the easy availability of samples.
Recent large-scale sequencing studies have identified putative driver genetic events of CLL, uncovered the vast inter-personal and intratumoral genetic heterogeneity in CLL and have linked the presence of aggressive subclonal mutations with clonal evol…
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