CORDIS Project
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This project explores the mechanisms of T cell tolerance in the immune system, focusing on how certain cells are eliminated or reprogrammed. By analyzing T cell receptors, it aims to clarify the balance between these processes and their implications for autoimmune diseases.
Self-tolerance is a key feature of the immune system; its failure causes autoimmune diseases such as Multiple Sclerosis or Type-1-Diabetes.
Remarkably, T cell tolerance operates via two fundamentally different mechanisms: potentially dangerous cells are either eliminated (clonal deletion) or re-programmed to differentiate into regulatory T (Treg) cells (clonal diversion).
Paradoxically, both tolerance modes can ensue from self-antigen-encounter in the thymus, and the parameters specifying these…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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