CORDIS Project
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This project explores how epithelial cancers evolve through genetic mutations and the mechanisms that allow these mutations to thrive despite protective strategies in normal tissue. By studying the dynamics of mutant clones, it aims to inform new prevention and treatment strategies for early-stage cancer.
Epithelial cancers are thought to evolve through a competitive process of mutation and selection in which the serial acquisition of oncogenic mutations confers an increasing fitness advantage, culminating in neoplastic transformation, tumour invasion, and metastasis.
This programme often initiates through a phase of field cancerization in which mutant clones expand within the context of physiologically normal-looking tissue.
To mitigate the risks associated with field cancerization, protection s…
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Germany, Dresden
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
South Korea, DAEJEON
Type: Research institute
Activity type: Research Organisations
SME: No
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