CORDIS Project
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CNSentinels aims to explore the protective role of macrophages in the central nervous system against infections. By employing innovative techniques, it seeks to understand the mechanisms governing immune responses and develop new therapeutic strategies for brain health.
Due to the vital importance of the Central Nervous System (CNS), its infection and inflammation have to be tightly controlled.
The surface of the CNS is connected to the periphery by a rich and complex tissue, the meninges.
They contain a vast network of macrophages subdivided in two populations endowed with elusive functions.
Using innovative depletion strategies in experimental mouse models, I discovered that meningeal macrophage populations represent the first line of protection against neuro…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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