CORDIS Project
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This project explores the mechanisms of protein complex assembly during translation, focusing on co-co assembly of nascent chains. It employs advanced imaging and biochemical techniques to understand how these processes are regulated in cells.
Almost all fundamental biological processes involve protein complexes and therefore, efficient folding and assembly of homo- and hetero-oligomers is critical for cellular functionality and integrity.
Recent studies have shown that many protein complexes assemble co-translationally by one fully-synthesized subunit engaging another subunit that is still in nascent state (co-post assembly).
An ongoing study in the Bukau lab now revealed that assembly can also occur by interaction of two partner nas…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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