CORDIS Project
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This project aims to develop new antimicrobial therapies targeting the Coenzyme A biosynthesis pathway in drug-resistant microorganisms, particularly focusing on tuberculosis. By using innovative fragment-based approaches, the project seeks to create potent inhibitors that can combat multiple pathogens effectively.
The increasing prevalence of drug-resistant microorganisms worldwide and the shortage of novel antimicrobial chemotherapeutics in the pipeline places our capacity to treat infectious diseases under serious threat.
Antimicrobial chemotherapies with novel modes of action are desperately needed.
However, the development of such therapies is a formidable task associated with a high failure rate.
This has been partly attributed to the limited diversity of high-throughput screening libraries and diffi…
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