CORDIS Project
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This research explores how cells regulate gene expression in response to environmental changes, focusing on the SAGA complex in yeast. The project aims to uncover the mechanisms by which this complex influences cell differentiation and responds to nutrient signals.
How a cell responds to developmental or environmental changes by altering gene expression is a fundamental question in biology.
Onecritical level of regulation is transcription initiation, which is controlled by large multiprotein complexes, including coactivators.
Many studieshave shown that coactivators have distinct activities that play crucial roles in transcription, and their perturbation can cause cancer orneurodegeneration.
Little is known, however, about how these activities integrate ex…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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