CORDIS Project
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This project investigates the evolutionary changes in the genetic code of yeast, particularly focusing on the CUG codon's reassignment. It aims to explore the mechanisms behind these changes and the potential role of a killer toxin affecting tRNA translation.
The genetic code was established at a very early stage during the evolution of life on Earth and is nearly universal.
In eukaryotic nuclear genes, the only known examples of a sense codon that underwent an evolutionary change of meaning, from one amino acid to another, occur in yeast species.
The codon CUG is translated as Leu in the universal genetic code, but it has long been known to be translated as Ser in some Candida species.
In recent work, we discovered that this switch is one of three p…
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
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