CORDIS Project
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This project explores the evolutionary implications of codon usage in human viruses, focusing on how maladaptation can enhance viral survival against immune responses. It combines molecular biology and experimental evolution to understand the fitness effects of codon bias in viral infections.
Fidelity during information transfer is essential for life, but it pays to be unfaithful if it provides an evolutionary advantage.
The immune system continuously generates diversity to put up with recurrent pathogen challenges, and many viruses, in its turn, have evolved mechanisms to generate diversity to evade immune restrictions, even at the cost of enduring high mutation rates.Synonymous codons are not used at random and are not translated with similar efficiency. A large proportion of virus…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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