CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the role of co-factors in the aggregation of tau protein, which is linked to neurodegenerative diseases like Alzheimer's. By exploring how these interactions influence tau structure and pathology, the research aims to redefine tau strains and enhance drug discovery for tauopathies.
Tau is an intrinsically disordered protein that regulates microtubule activity in neurons.
Aggregation of tau into amyloid fibrils is diagnostic of several diseases, termed tauopathies, that include Alzheimer's disease.
Distinct amyloid aggregate structures, so-called ""strains"", are involved in different tauopathies.
These assemblies can spread and recapitulate pathological phenotypes when injected in cells and animals.
This is the hallmark that tau aggregates follow a prion behaviour.
To date…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
Guests see up to 5 keywords.
