CORDIS Project
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This project focuses on developing a targeted treatment for cancers with STAG2 mutations, such as bladder cancer and acute myeloid leukaemia. By inhibiting the STAG1 protein, the project aims to create a precision medicine that selectively targets cancer cells while sparing healthy cells, reducing side effects and impr…
The cohesin gene STAG2 has emerged as a new tumour suppressor frequently mutated in bladder cancer, Ewing sarcoma and acute myeloid leukaemia (AML).
Currently, these cancers are treated by cytotoxic therapies and surgery.
These treatment plans are limited by unwanted side effects, have not been able to eliminate the high mortality caused by AML, and have not improved over the last few decades. STAG2 mutations are therefore a biomarker for cancer patients with high medical need.
We discovered tha…
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