CORDIS Project
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This project investigates the mechanisms behind the formation and maintenance of chromatin loops, which are crucial for gene expression regulation. By employing advanced genetic and imaging techniques, the research aims to elucidate how the cohesin complex organizes chromosomes within the cell nucleus.
The 3D organization of chromosomes within the nucleus is of great importance to control gene expression.
The cohesin complex plays a key role in such higher-order chromosome organization by looping together regulatory elements in cis.
How these often megabase-sized looped structures are formed is one of the main open questions in chromosome biology.
Cohesin is a ring-shaped complex that can entrap DNA inside its lumen.
However, cohesin’s default behaviour is that it only transiently entraps and…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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