CORDIS Project
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This project focuses on developing a targeted method to eliminate harmful bacteria while preserving beneficial gut microbiota. By using engineered genetic modules that activate only in specific pathogens, it aims to create a selective antimicrobial strategy against bacteria like Salmonella and Shigella, tested initiall…
Targeted killing of pathogenic bacteria without harming beneficial members of the host microbiota holds promise as a strategy to cure disease and limit both imbalances in the microbiota and development of antimicrobial resistance.
Recent work from the Unité de Plasticité du Génome Bactérien has demonstrated that genetic modules based on toxin-intein systems delivered by conjugation are highly effective antimicrobials agents, able to selectively kill Vibrio cholerae in mixed populations.
In this…
INSTITUT PASTEUR
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